The definitive reference on pediatric oncology is now in its thoroughly revised, updated Fourth Edition. A multidisciplinary group of the world's foremost specialists presents state-of-the-art information and guidelines on every aspect of pediatric cancer--from molecular biology to diagnosis, multimodal therapy, and supportive care.This edition features greater integration of the biologic and genetic factors affecting diagnosis and treatment. New chapters discuss incidence and trends in childhood cancer, evolving molecular and targeted therapies, and training strategies to develop humanistic skills in the pediatric hematologist-oncologist. Also included are up-to-date listings of support resources for children with cancer and for their families and physicians
1 General Principles of the Epidemiology of Childhood Cancer 1
2 Childhood Cancer, Heredity, and the Environment 11
3 Molecular Basis of Childhood Cancer 37
4 Growth Factors, Cytokines, and Differentiation Factors in
Childhood Cancer 75
5 Tumor Immunology and Pediatric Cancer 103
6 Clinical Assessment and Differential Diagnosis of the Child
With Suspected Cancer 129
7 Pathology and Molecular Diagnosis of Pediatric Malignancies
141
8 Imaging Studies in the Diagnosis of Pediatric Malignancies 187
9 General Principles of Chemotherapy 215
10 General Principles of Surgery 273
11 General Principles of Radiation Therapy 289
12 Principles of Immunotherapy 323
13 Special Considerations for the Infant with Cancer 343
14 Bone Marrow Transplantation in Pediatric Oncology 357
15 The Applications of Gene Transfer to Pediatric Malignant
Disease 375
16 Cancer Clinical Trials: Design, Conduct, Analysis, and
Reporting 385
17 Acute Lymphoblastic Leukemia 409
18 Acute Myelogenous Leukemia 463
19 Chronic Leukemias of Childhood 483
20 Myeloproliferative and Myelodysplastic Syndromes 505
21 Hodgkin`s Disease 523
22 Malignant Non-Hodgkin`s Lymphomas in Children 545
23 Lymphoproliferative Disorders 589
24 The Histiocytoses 615
25 Tumors of the Central Nervous System 633
26 Retinoblastoma 699
27 Hepatic Tumors 717
28 Wilms Tumor 733
29 Neuroblastoma 761
30 Rhabdomyosarcoma and the Undifferentiated Sarcomas 799
31 Ewing`s Sarcoma Family of Tumors: Ewing`s Sarcoma of Bone and
Soft Tissue and the Peripheral Primitive Neuroectodermal Tumors
831
32 Other Soft Tissue Sarcomas of Childhood 865
33 Osteosarcoma 889
34 Germ Cell Tumors 921
35 Endocrine Tumors 947
36 Managment of Infrequent Cancers of Childhood 977
37 Pediatric AIDS and Childhood Cancer 1005
38 Oncologic Emergencies 1025
39 Hematologic Supportive Care of the Pediatric Cancer Patient
1051
40 Infectious Complications in the Pediatric Cancer Patient 1069
41 The Role of Hematopoietic Cytokines in Supportive Care 1115
42 Nutritional Supportive Care 1167
43 Management of Cancer Pain in Children 1183
44 Management of Nausea and Vomiting 1201
45 Nursing Support of the Child With Cancer 1209
46 Rehabilitation of the Child with Cancer 1229
47 Psychiatric and Psychosocial Support for the Child and Family
1241
48 The Other of Side of the Bed: What Caregivers Can Learn from
Listening to Patients and Their Families 1267
49 Ethical Considerations in Pediatric Oncology 1283
50 Late Effects of Childhood Cancer and Its Treatment 1303
51 Educational Issues for Children with Cancer 1331
52 Care of the Dying Child 1343
53 Financial Issues in Pediatric Cancer 1357
54 Pediatric Cancer: Advocacy, Legal, Insurance, and Employment
Issues 1367
55 Alternative Therapies in the Treatment of Childhood Cancer
1383
56 Pediatric Oncology in Countries With Limited Resources
57 Preventing Cancer in Adulthood: Advice for the Pediatrician
1421
58 Resources for Children with Cancer and for Their Families and
Physicians 1437
Index 1489
