Comprehensive overview of the value of cutting-edge MRI for the assessment of normal and diseased skeletal muscle
Presents research findings in respect of the role of modern morphological and functional MRI techniques
Provides examples of the added value provided by these techniques when evaluating muscular diseases
Although muscular diseases are a huge and heterogeneous group, in most cases of progressive disease the result is focal or general muscular weakness that presents as an unspecific symptom. Imaging techniques that offer differential diagnostic clues are therefore urgently needed. Despite this, MRI has to date often been assigned a subsidiary role in the diagnostic work-up of these diseases owing to the frequent inability of routine MRI protocols to detect pathognomonic findings.
This situation is changing with the advent of modern MRI techniques that offer deeper insights into surrogate pathophysiologic parameters, such as muscular microcirculation, sodium homeostasis, energy and lipid metabolism, and muscle fiber architecture. Much higher levels of acceptance and demand by clinicians can be anticipated for these new techniques in the near future, and radiologists will have to face up to the increasing value of MRI of the skeletal musculature.
In this book, recognized experts from around the world provide a comprehensive overview of the value of cutting-edge MRI for the assessment of normal and diseased skeletal muscle. A range of aspects are covered, from the general role of MRI in imaging the skeletal musculature, including in comparison with ultrasonography, through to the current value of MRI in the diagnostic work-up of different diseases. In addition, several chapters present research findings in respect of modern morphological and functional MRI techniques for assessment of the skeletal musculature and provide examples of the added value provided by these techniques when evaluating muscular diseases.
Part I Role of MRI in Imaging the Skeletal Musculature
Imaging of Skeletal Muscle in Neuromuscular Disease:
A Clinical Perspective . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Craig M. Zaidman and Lisa D. Hobson-Webb
Correlation of Skeletal Muscle Anatomy to MRI and US Findings . . . . . . . . . . 27
Alberto Tagliafico, Bianca Bignotti, Sonia Airaldi and Carlo Martinoli
Imaging the Skeletal Muscle: When to Use MR imaging
and When to Use Ultrasound. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Carlo Martinoli, Sonia Airaldi, Bianca Bignotti and Alberto Tagliafico
Part II Modern MRI Techniques for Assessment
of the Skeletal Musculature
Whole-Body MRI for Evaluation of the Entire Muscular System . . . . . . . . . . . 55
Nicolai Schramm, Sabine Weckbach, Stephen Eustace and Niamh M. Long
Diffusion-Weighted and Diffusion Tensor Imaging:
Applications in Skeletal Muscles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Usha Sinha and Shantanu Sinha
Assessment of Skeletal Muscle Microperfusion Using MRI . . . . . . . . . . . . . . . . 87
Sasan Partovi, Bjoern Jacobi, Yaron Gordon, Lisa Zipp, Anja-Carina Schulte,
Sasan Karimi, Rolf Huegli and Deniz Bilecen
Skeletal Muscle MR Imaging Beyond Protons: With a Focus
on Sodium MRI in Musculoskeletal Applications . . . . . . . . . . . . . . . . . . . . . . . 115
Armin M. Nagel, Marc-André Weber, Arijitt Borthakur and Ravinder Reddy
MR Spectroscopy and Spectroscopic Imaging for Evaluation of Skeletal
Muscle Metabolism: Basics and Applications in Metabolic Diseases. . . . . . . . . . 135
Chris Boesch
Dynamic MR Imaging of the Skeletal Musculature: From Static Measures
to a Dynamic Assessment of the Muscular (Loco-) Motion . . . . . . . . . . . . . . . . 165
Shantanu Sinha and Usha Sinha
xi
Part III MRI in the Diagnostic Work-up of the Skeletal Musculature
MRI of Muscle Injuries . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187
Simon Dimmick, Christoph Rehnitz, Marc-André Weber and James M. Linklater
MRI of Muscle Denervation in Central and Peripheral
Nervous System Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221
Mirko Pham, Marcel Wolf, Philipp Bäumer, Martin Bendszus and Gregor Kasprian
MRI in Muscle Dystrophies and Primary Myopathies. . . . . . . . . . . . . . . . . . . . 241
Dirk Fischer and Mike P. Wattjes
MRI in Inflammatory Myopathies and Autoimmune-Mediated Myositis . . . . . . 255
Umesh A. Badrising, Hermien E. Kan and Jan JGM Verschuuren
MRI in Muscle Channelopathies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271
Karin Jurkat-Rott, Marc-André Weber and Frank Lehmann-Horn
MRI in Muscle Tumors and Tumors of Fasciae and Tendon Sheaths . . . . . . . . 289
F. M. Vanhoenacker, M. E. A. P. M. Adriaensen-van Roij and A. M. De Schepper
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309