The undisputed gold standard text in the field, Ryan's Retina is your award-winning choice for the most current, authoritative information on new technologies, surgical approaches, scientific advances and diagnostic and therapeutic options for retinal diseases and disorders. Packed with timely updates throughout, new illustrations, and a dedicated team of editors who extend Dr. Ryan's legacy in retina, this outstanding 6th Edition is a must-have reference for retinal specialists, ophthalmologists, and fellows in training.
New to this Edition
Bullets Includes new chapters on widefield imaging, intraoperative OCT imaging, medical management of diabetes mellitus and age-related macular degeneration, and senile retinoschisis.
Includes more than 1,150 brand-new illustrations, scans, and photographs throughout.
Covers the explosion of new imaging options across optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging, including a greatly expanded OCT imaging chapter that features crucial information on OCT-Angiography (OCT-A).
Presents new pharmacotherapy data and the latest approaches in anti-VEGF therapy for age-related macular degeneration, diabetic retinopathy, and venous occlusive disease.
Features an expanded online video library highlighting the latest surgical techniques and new coverage of complications of vitreoretinal surgery.
Contains thorough content updates in every area of retina, including advanced imaging technologies, gene therapy, inflammation and immune responses, white dot syndromes, epigenetic mechanisms, transplantation frontiers to improve retinal function, macular hole, myopic eye disease, ocular trauma, drug delivery to the posterior segment, advances in macular surgery, vitrectomy and complex retinal detachment, tumors, and retinal genetics and biology.
Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
Key Features
Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology.
Provides a truly global perspective from five highly esteemed section editors and more than 350 other world authorities from across Europe, Asia, Australasia, and the Americas.
Author Information
By Andrew P. Schachat, MD, Vice Chairman, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA ; Charles P. Wilkinson, MD MD, Chairman, Department of Ophthalmology, Greater Baltimore Medical Center; Professor, Department of Ophthalmology, John Hopkins University, Baltimore, MD, USA Chairman, Department of Ophthalmology, Greater Baltimore Medical Center and Professor, Department of Ophthalmology, Johns Hopkins University, Baltimore, MD, USA; David R. Hinton, MD, Gavin S. Herbert Professor of Retinal Research; Professor of Pathology and Ophthalmology, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA ; SriniVas R. Sadda, MD, Associate Professor of Ophthalmology, Doheny Eye Institue, Los Angeles, CA, USA and Peter Wiedemann, MD, Professor and Chair, Department of Ophthalmology, University of Leipzig, Leipzig, Germany
Part I: Retinal Imaging and Diagnostics
1. Fluorescein Angiography: Basic Principles and Interpretation
2. Clinical Applications of Diagnostic Indocyanine Green Angiography
3. Optical Coherence Tomography
4. Autofluorescence Imaging
5. Widefield Imaging
6. Intraoperative OCT Imaging
7. Advanced Imaging Technologies
8. Advanced Image Analysis
9. Electrogenesis of the Electroretinogram
10. Clinical Electrophysiology
11. Diagnostic Ophthalmic Ultrasound
12. Color Vision and Night Vision
13. Visual Acuity and Contrast Sensitivity
14. Visual Fields in Retinal Disease
Part 2: Basic Science and Translation to Therapy
Section 1: Anatomy and Physiology
15. The Development of the Retina
16. Structure and Function of Rod and Cone Photoreceptors
17. Function and Anatomy of the Mammalian Retina
18. Cell Biology of the Retinal Pigment Epithelium
19. Cell Biology of Retinal Glia
20. Retinal and Choroidal Vasculature: Retinal Oxygenation
21. Mechanisms of Normal Retinal Adhesion
22. Structure, Function, and Pathology of Bruch's Membrane
23. Vitreous and Vitreoretinal Interface
Section 2: Basic Mechanisms of Injury in the Retina
24. Mechanisms of Oxidative Stress in Retinal Injury
25. Mechanisms of Endoplasmic Reticulum Stress in Retinal Disease
26. Cell Death, Apoptosis, and Autophagy in Retinal Injury
27. Inflammation and Immune Responses In Retinal Health and Disease
28. Basic Mechanisms of Pathological Retinal and Choroidal Angiogenesis
29. Blood-Retinal Barrier, Immune Privilege, and Autoimmunity
30. Mechanisms of Macular Edema and Therapeutic Approaches
31. Cellular Effects of Detachment and Reattachment on the Neural Retina and the Retinal Pigment Epithelium
32. Pathogenesis of Serous Detachment of the Retina and Pigment Epithelium
Section 3: Genetics
33. Genetic Mechanisms of Retinal Disease
34. Mitochondrial Genetics of Retinal Disease
35. Epigenetic Mechanisms of Retinal Disease
Section 4: Translational Basic Science
36. Gene Therapy for Retinal Disease
37. Stem Cells and Cellular Therapy
38. Nanomedicine in Ophthalmology
39. Neuroprotection
40. Drug Delivery
41. Retinal Laser Therapy: Biophysical Basis and Applications
Medical Retina
Section 1: Retinal Degenerations and Dystrophies
42. Retinitis Pigmentosa and Allied Disorders
43. Hereditary Vitreoretinal Degenerations
44. Macular Dystrophies
45. Hereditary Choroidal Diseases
46. Abnormalities of Cone and Rod Function
Section 2: Retinal Vascular Disease
47. The Epidemiology of Diabetic Retinopathy
48. Diabetic Retinopathy: Genetics and Etiologic Mechanisms
49. Medical Management of Diabetes Mellitus
50. Nonproliferative Diabetic Retinopathy and Diabetic Macular Edema
51. Proliferative Diabetic Retinopathy
52. Hypertension
53. Telescreening for Diabetic Retinopathy
54. Retinal Artery Occlusions
55. Acquired Retinal Macroaneurysms
56. Branch Vein Occlusion
57. Central Retinal Vein Occlusion
58. Macular Telangiectasia
59. Coats Disease
60. Hemoglobinopathies
61. Radiation Retinopathy
62. Ocular Ischemic Syndrome 
63. Coagulopathies
64. Pediatric Retinal Vascular Diseases Retinopathy of Prematurity
65. Telescreening for Retinopathy of Prematurity
Section 3: Choroidal Vascular/Bruch's Membrane Disease
66. Epidemiology and Risk Factors for Age-Related Macular Degeneration
67. Pathogenetic Mechanisms in Age-Related Macular Degeneration
68. Age-Related Macular Degeneration: Non-neovascular Early AMD, Intermediate AMD, and Geographic Atrophy
69. Neovascular (Exudative or "Wet") Age-Related Macular Degeneration
70. Pharmacotherapy of Age-Related Macular Degeneration
71. Pathologic Myopia
72. Angioid Streaks
73. Ocular Histoplasmosis
74. Polypoidal Choroidal Vasculopathy
75. Central Serous Chorioretinopathy
76. Uveal Effusion Syndrome and Hypotony Maculopathy
Section 5: Miscellaneous
92. Drug Toxicity of the Posterior Segment
93. Photic Retinal Injuries: Mechanisms, Hazards, and Prevention
94. Traumatic Chorioretinopathies 
95. Pregnancy-Related Diseases
96. Optic Disc Anomalies, Pits, and Associated Serous Macular Detachment
97. Retina-Related Clinical Trials: A Resource Bibliography
Surgical Retina
Section 1: The Pathophysiology of Retinal Detachment and Associated Problems
98. Pathogenetic Mechanisms of Retinal Detachment
99. Nonrhegmatogenous Retinal Detachment
100. Senile Retinoschisis
101. Pathogenesis of Proliferative Vitreoretinopathy 
102. Pathophysiology of Ocular Trauma
Section 2: Retinal Reattachment: General Surgical Principles and Techniques
103. The Effects and Action of Scleral Buckles in the Treatment of Retinal Detachment
104. Techniques of Scleral Buckling
105. Principles and Techniques of Vitreoretinal Surgery
106. Primary Vitrectomy in Rhegmatogenous Retinal Detachment
107. Pneumatic Retinopexy
108. Special Adjuncts to Treatment
109. Optimal Procedures for Retinal Detachment Repair
110. Prevention of Retinal Detachment
Section 3: Complicated Forms of Retinal Detachment
111. Proliferative Vitreoretinopathy
112. Retinotomies and Retinectomies
113. Giant Retinal Tear 
114. Surgery for Ocular Trauma: Principles and Techniques of Treatment
115. Surgery for Proliferative Diabetic Retinopathy
116. Management of Combined Inflammatory and Rhegmatogenous Retinal Detachment
117. High Myopia and the Vitreoretinal Complications
118. Surgical Management of Retinopathy of Prematurity
119. Surgery for Pediatric Vitreoretinal Disorders
Section 4: Vitreous Surgery for Macular Disorders
120. Epiretinal Membranes, Vitreoretinal Traction and Cystoid Macular Edema
121. Macular Hole
122. Surgical Management of Choroidal Neovascularization and Subretinal Hemorrhage
123. 360 Degree Macular Translocation
124. Retinal Pigment Epithelium and Choroid Translocation in Patients with Age-Related Macular Degeneration
Section 5: Vitreous Surgery: Additional Considerations
125. Infectious Endophthalmitis
126. Diagnostic and Therapeutic Vitrectomy for Uveitis
127 . Vitreous, Retinal, and Choroidal Biopsy
128. Transplantation Frontiers
129 . Artificial Vision
130. Pharmacology During Surgery
131. Complications In Vitreoretinal Surgery
Tumors of the Retina, Choroid, and Vitreous
Section 1: Tumors of the Retina
132. Retinoblastoma
133. Cavernous Hemangioma
134. Capillary Hemangioblastoma of the Retina and von Hippel-Lindau Disease
135. Tuberous Sclerosis and the Eye
136. Phakomatoses
137. Retinal Metastases
138. Remote Effects of Cancer on the Retina
139. Melanocytoma of the Optic Disc
140. Congenital Hypertrophy of the Retinal Pigment Epithelium
141. Combined Hamartoma of the Retinal Pigment Epithelium and Retina
Section 2: Tumors of the Choroid
142. Choroidal Nevi
143. Epidemiology of Posterior Uveal Melanoma
144. Prognosis of Posterior Uveal Melanoma
145. Molecular Genetics of Choroidal Melanoma
146. Pathology of Choroidal Melanoma
147. Overview of Management of Posterior Uveal Melanoma
148. Enucleation for Choroidal Melanomas
149. Brachytherapy for Choroidal Melanoma
150. Charged-Particle Irradiation of Uveal Melanoma
151. Surgical Resection of Choroidal Melanoma
152. Laser Treatment of Choroidal Melanoma
153. Systemic Evaluation and Management of Patients with Metastatic Uveal Melanoma
154. Collaborative Ocular Melanoma Study
155. Choroidal Metastases
156. Choroidal Osteoma
157. Circumscribed Choroidal Hemangioma
Section 3: Hematologic and Miscellaneous Tumors
158. Miscellaneous Uveal Tumors
159. Leukemias and Lymphomas
160. Primary Vitreoretinal Lymphoma
